Chem. Pharm. Bull. 55(8) 1218—1221 (2007)
نویسندگان
چکیده
lation of five neo-clerodane diterpenoid alkaloids from the aerial parts of Scutellaria barbata. As part of our continuing work to discover more novel neo-clerodane diterpenoids, we have re-investigated the aerial parts of this species and isolated the previously isolated scutebarbatine B (6), scutebarbatine D (7) and scutebarbatine F (8), together with five new neo-clerodane diterpenoid alkaloids scutebarbatine G (1), 6,7-di-O-nicotinoylscutebarbatine G (2), 6-O-nicotinoyl-7-Oacetylscutebarbatine G (3), scutebarbatine H (4) and 7-Onicotinoylscutebarbatine H (5). By means of detailed spectral analyses, the structures of five new compounds (1—5) were established. In addition, five new compounds were screened for cytotoxity against three tumor cell lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), with IC50 values being in the range 3.4—8.5 mM. We report here on the isolation, structure elucidation, as well as the evaluation of cytotoxic effects of these five new compounds.
منابع مشابه
Antiinflammatory Constituents of Teramnus labialis
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